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In a series of papers [3436], Ookhtens and colleagues showed that the half-life of glutathione in the liver was quite low, approximately 23 hours, consistent with the result of Lauterburg [47]

The ChaC family (ChaC1 and ChaC2, cytoplasmic glutathione-specific -glutamyl cyclotransferases) has recently been shown to take part in GSH metabolism

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples

Collectively, these multisystem observations support the concept that anabolicandrogenic steroid toxicity represents a diffuse endocrinemetabolic disorder rather than isolated organ-specific pathology