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At the top, an L-lysine residue within a peptide is methylated by a methyltransferase using S-adenosylmethionine as a methyl donor, forming - N -trimethyllysine
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PubMed laboratory research record [PMID: 30597617] PubMed record related to this compound for laboratory literature review
Since the efficiency of PROTACs can be cell-type specific, we validated our compounds in two AML cell lines, NB-4 and OCI-AML2, but again we were unable to detect any degradation of RNF4 upon exposure to the CCW16-based degraders at different concentrations and time points ( Supplementary Figure 2C, D )
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