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Zafereo ME , Wang J
However, other (TBK1-independent) activities of mutant p53 may also affect the tumor microenvironment
1 2 3 PDB: 1N0J
The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
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