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In the gutkidney axis, barrier disruption may accelerate systemic toxin exposure and promote renal damage [356, 358], while in the gutheart axis, it may contribute to endothelial dysfunction and chronic vascular inflammation [359]

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10.1016/S0753-3322(03)00043-X

Oral glutathione appears safe in the short term, but long-term safety data remains limited, and intravenous forms have been associated with adverse effects

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