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Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

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The arginine accumulation within tumor cells can activate mTORC1 signal transduction and aid in tumor growth and metabolic adaptation, while aspartic acid can participate in tumor cell nucleotide synthesis and TCA cycle (Tajan et al., 2018

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