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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
Her clinical focus is to help patients reduce their waist circumference so it reduces pressure on the heart
doi: 10.1038/nm1611 90 PandolfiJFerraroALernerMSerranoJRDueckAFainboimLet al
This contextual understanding should be interpreted with a qualified healthcare provider alongside objective clinical assessment
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