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Table I [i] PIO pioglitazone, GLP-1R glucagon-like peptide 1 receptor, SGLT2 sodium-glucose co-transporters 2, TOFO tofogliflozin, SUL sulfonylurea, MET metformin, DAPA dapagliflozin, EXE exenatide, NAFLD non-alcoholic fatty liver disease, T2D type 2 diabetes, A1C glycated hemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase, -GT gamma-glutamyl transferase, MRI-PDFF MRI-proton density fat fraction, MRE-LSM MR elastography-liver stiffness, RCT randomized controlled trial, EDICT Efficacy and Durability of Initial Combination Therapy, CAP controlled attenuation parameter, LSM liver stiffness measurement, BMI body mass index

[7] For weight management, NICE (TA875) recommends semaglutide 2.4 mg for adults with a BMI of 35 kg/m or greater (or 30 kg/m or greater with at least one weight-related comorbidity), or 30 kg/m (or 27.5 kg/m with comorbidities) for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean family backgrounds

Recently, Sun et al

Unlike GLP-1, supraphysiologic GIP infusions do not amplify the late phase insulin response to glucose in patients with T2DM (17, 18)