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The mechanism of action involves several pathways: Appetite regulation : Semaglutide acts on receptors in the brain (particularly in the hypothalamus) to reduce hunger and increase feelings of fullness, leading to decreased calorie intake
In fact, weight loss due to a major decline in lean body mass is normally associated with a decline in skeletal muscle mass and strength, resulting in an increased risk of sarcopenia, impaired glucose sensitivity, and poor glucose control ( The liver plays a central role in the regulation of lipid metabolism as it is the foremost site of lipid uptake, synthesis, oxidation, and distribution to peripheral tissues
