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The National Institute on Drug Abuse (NIDA) warns that individuals recovering from opioid addiction are at risk of relapse if exposed to these opioid-acetaminophen combinations

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and Rao, J.Y., 2006

Glutathione-responsive nanosystems are engineered to remain stable in circulation but undergo structural changes or drug release specifically in high-GSH tumor cells, improving therapeutic precision and reducing off-target toxicity