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692,693 Mutations in key TCA cycle enzymes, such as SDH, fumarate hydratase, and IDH, lead to TCA cycle dysfunction and mitochondrial metabolic defects across various human cancers

Epub 2018 Nov 22

Traditionally GLP-1(9-36) was considered inactive, however more recent studies indicate that GLP-1(9-36) can contribute to inhibiting glucagon secretion by inhibiting voltage-gated calcium channels through a GPCR mechanism, an effect which reduces the number of glucagon containing vesicles that are available for exocytosis, thereby contributing the the decrease in glucagon secretion (Figure 1)(Zheng et al, 2024)

As a specific example: do these multi-agonists act simultaneously at multiple receptors residing at a single tissue or even a single cell