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I prescribe these medications as frequently as I can when warranted
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However, as suggested by a previous MR study [23], uric acid is downstream of l-carnitine, i.e., a mediator, so we did not exclude it as an invalid genetic instrument
The article says meta-analyses suggest berberine reduces fasting glucose by 10 to 15 mg/dL in type 2 diabetes patients, with HbA1c improvements of roughly 0.5 to 1.0 percentage points
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