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Even a single amino acid substitution can dramatically alter the peptide's properties and render it ineffective
Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain
432 Approximately 1.5 million people a year in the United States have some type of joint replacement surgery
Total daily doses of 300 mg, 450 mg, or 600 mg can reduce pain by more than 30% if the patient can tolerate the side effects of dizziness, somnolence, dry mouth, weight gain, and peripheral edema, especially at 600 mg
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