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Ravanel et al., 1998b)
This directly complicates patient screening and enrollment, leads to substantially lower overall expected efficacy compared with patients harboring upstream genetic defects (such as POMC deficiency) [56] , and results in a low statistical success rate in large-scale trials
Altering substituents on the aromatic rings can significantly change binding affinity to NNMT
Microdosing GLP-1s is generally better tolerated (fewer side effects like nausea) due to the lower drug exposure, but the overall safety profile is the same as the standard dose
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