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Here we have identified that depletion of -ketoglutarate (KG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation

Higher doses are considered when patients do not meet glycemic targets or experience a plateau in weight loss despite adherence

Numerous studies have identified abnormal alterations in various cytokines in the CSF and peripheral blood of SZ patients (see Table 3 ), most of which are pro-inflammatory cytokines (IL-1, IL-2, IL-8, TNF-, and IFN-) (188191), with a smaller proportion being anti-inflammatory cytokines (including TGF-1, IL-4, and IL-10) (192)

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