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A reasonable candidate is someone who: Is already following a structured, clinician-supervised nutrition and activity plan Has a documented B12 deficiency or a condition that impairs B12 absorption Cannot tolerate GLP-1 medications, or is not a candidate for them Declines prescription pharmacotherapy and wants a non-stimulant, non-surgical adjunct Understands because the clinician has said so plainly that the injection is a supporting player A poor candidate is someone who wants the shot instead of the program

According to the National Institutes of Health, oral B12 has a 1 to 2 percent absorption rate

You can, but night dosing reduces bioavailability by 3540% compared to morning fasted-state administration