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Previous studies with Tko characterized three DNA repair enzymes that resolve dU damage

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For example, the expression level of neurotensin 1 (Nts1) in mice fed CR diet was significantly increased within 1 month, while the gene expression of CpG sites in the promoter region of Nts1 gene was significantly decreased in mice fed normal diet, which indicated that CR had a long-term effect on the memory of cells (Unnikrishnan et al., 2017)

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