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Beyond directly influencing pathological changes in the AD brain, BAs may provide neuroprotective benefits by modulating the microbiotagutbrain (MGB) axis, which supports memory function

Nuclear NAD + is generated by nuclear NMNAT1 and is largely utilized by PARPs for DNA damage response and nuclear sirtuins such as SIRT1, SIRT6 or SIRT7 for epigenetic deacetylation 82,86