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BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia

For first-time users: Start with a dose of 2.5mg

Inhibition of Glucagon Release GLP-1 helps regulate blood sugar by inhibiting glucagon, a hormone that triggers the liver to release stored glucose, which can raise blood sugar levels