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This reduction in estrogen can cause several issues, including: Weight Gain: Estrogen plays a role in regulating fat storage and distribution
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This might result from the differences in the types of antithrombotic medications administered
A hypothetical plan size of 1 million lives was assumed, and the following steps were applied to arrive at the eligible population: proportion of the population who are adults (77.8%), T2DM prevalence among adults in the USA (8.6%), proportion of patients with T2DM who receive metformin (41.0%), and proportion for whom metformin has failed (48.0%) [17, 46,47,48]
