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Compound 3 was isolated by silica gel column chromatography using a dichloromethane/methanol (DCM:MeOH = 40:1, V/V) eluent (yield: 75%)

Pancreatitis occurs when these powerful digestive enzymes activate prematurely while still inside the pancreas, leading the organ to essentially start digesting itself

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Modifications within the peptide backbone and sequence influence receptor binding behavior and resistance to enzymatic degradation in biochemical environments