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Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signaling
Pancreatic ductal adenocarcinoma (PDAC) is another example where TDEs regulate various aspects of tumor behavior, including angiogenesis (miR-27a, VEGFC), cancer-associated thrombosis (TF, ANXA1), immune evasion (H2AF, PKM2), stromal reprogramming, chemoresistance, metastasis, and tumor growth (miR-27a, mir-194-5p, ANXA1, miR-222) through the delivery of specific cargo [32]
