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Depending on the dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), by several P450 cytochromes [34]
However, it is still a Schedule II controlled substance with a significant risk of dependence and addiction, especially at high doses or when misused
It is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephritic syndrome
Mechanisms of Action: How MOTS-C Remodels Metabolism Understanding the MOTS-c dosage chart requires understanding the mechanisms it targets, because dose-response relationships in peptide biology are rarely linear
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