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PARP-1 contributes significantly by selectively binding to cisplatin-induced DNA damage, particularly 1, 2-d(GpG) crosslinks ( Table 4 )
Our genomic analysis showed a near absence of GSH system in these organisms [Additional file 1
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Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level , where it protects the liver cells from toxic molecules: in this case, Glutathione "binds" to the toxic metabolites, neutralizing them
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