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NICE guidance requires at least 5% weight loss after 6 months at maintenance dose for treatment continuation, with maximum recommended duration of 2 years
Meanwhile, the most frequently reported adverse effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, and diarrhea ( In previous real-world studies of GLP-1 RAs-induced hypoglycemia, lixisenatide showed the strongest association (Zhao et al., 2021), consistent with our finding (Figure 2)
Amylin analogues act directly on the brain
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