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That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them
Deu 20 mg significantly inhibits CYP2C19, reducing the conversion of clopidogrel to its active antiplatelet metabolite thereby substantially reducing its antiplatelet efficacy and potentially increasing the risk of adverse cardiovascular events (heart attack, stroke, stent thrombosis) in patients with coronary artery disease
10.1016/j.molmet.2015.07.008 70
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