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Originally developed as an anti-obesity drug, AOD-9604 is a synthetic fragment derived from human growth hormone (hGH), specifically the 177-191 amino acid sequence

This dominance is largely attributed to the widespread use of glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide (Wegovy) and tirzepatide (Zepbound), which have shown significant effectiveness in weight management

Two HGF protease inhibitors have been identified, HGF activator inhibitor (HAI)-1 and/or HAI-2, which control the activation of HGF ligand to limit the production of active HGF (Mizuno and Nakamura, 2013)