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Obesity leads to a constant state of low-grade inflammation, which not only makes arthritis pain and swelling worse but also raises your risk for diabetes, heart attacks, and even early death
As an investigational compound it has not completed and at the time of writing has not reported a dedicated cardiovascular-outcomes trial, so there is no evidence yet that it reduces heart attacks or strokes
To avoid this, its recommended to take L-carnitine with food
In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+
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