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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

Speranza B, Campaniello D, Monacis N, Bevilacqua A, Sinigaglia M, Corbo MR

Preclinical models: Humanized GA models incorporating dietary/metabolic stressors are needed to recapitulate FA-immune interactions (241)

Clinical trials have shown strong weight loss results in adults, but data on nursing individuals and the transfer of the drug into breast milk remain limited