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Safety and tolerability of RYBELSUS were evaluated across 10 different clinical trials 1-4,a Safety and tolerability of RYBELSUS were evaluated across 10 different clinical trials 1-4,a The most frequently reported adverse reactions were GI disorders, including nausea, abdominal pain, and diarrhea Nausea, vomiting, and/or diarrhea occurred mostly during dose escalation 4% and 8% of patients discontinued RYBELSUS 7 mg and 14 mg, respectively, due to GI adverse reactions, compared to 1% of patients receiving placebo GI=gastrointestinal

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Patients and providers can report side effects to the FDA MedWatch program, which collects safety data

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