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High dose vitamin C is generally synergistic with glutathione (vitamin C actually recycles oxidized glutathione back to its active form), but mega doses above 2,000 mg taken at the same moment as oral glutathione can compete for absorption in the gut
The process is typically pretty quick and can take up to an hour, depending on the therapy you need
Glutathione metabolism in cancer progression and treatment resistance
doi: 10.3390/biomedicines11051388 44 RukavinaMNKouyoumdzianNMChoiMR
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