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The SURPASS-CVOT trial (NCT04255433) will assess the cardiovascular safety of tirzepatide compared to dulaglutide in people with T2D and established atherosclerotic disease [111]
In addition, the accumulation of acylcarnitine in the pathological state of the liver leads to insulin resistance, which further aggravates the development of liver diseases and results in a vicious cycle [211]
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