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For example, microsatellite stable colorectal cancer (MSS CRC) cells accumulate distal cholesterol precursors (DCPs) due to asynchronous cholesterol biosynthesis, polarizing T cells toward a pro-tumorigenic Th17 phenotype and promoting immune suppression
These side effects are usually mild to moderate and tend to improve over time with gradual dose escalation
These usually resolve within hours to a few days
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