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Contrariwise, in the study by Jensterle et al
Recent studies clearly show that the only real way to achieve significant weight loss, and especially to maintain these losses long-term, relies largely on a sustained reduction in energy intake
On-Treatment Analysis (If Everyone Stayed on Max Dose): CagriSema achieved 22.7% weight loss using trial-product estimand (assumes perfect adherence at max dose)
However, most of the symptom improvement occurs during the first week
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