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It was initially postulated to be a compensatory mechanism to the blood pressure lowering effect of GLP-1 RAs that was possibly mediated by their vasodilatory effect [9, 31] and/or increased urinary sodium excretion [32]
[1] The black color and characteristic strong odor are caused by hemoglobin in the blood being altered by digestive enzymes and intestinal bacteria
Never discontinue or adjust GLP-1 medication without medical guidance, particularly if prescribed for diabetes management, as this may affect glycaemic control
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