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The mechanisms underlying the favorable cardiovascular effects of GLP-1RAs remain incompletely understood

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The study included both in vivo analysis from two phase 2 clinical trials and in vitro experiments using primary human hepatocytes

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Retatrutide activates three hormone receptors: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors

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