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In nucleated cells, their functions are not limited to apoptosis, and caspases have been demonstrated to be involved in the regulation of multiple RCDs and related mechanisms, including pyroptosis (caspase-1), necroptosis (caspase-8), mitotic catastrophe (caspase-2), and regulation of inflammation [4]
Most experimental research has been conducted in in vitro systems and animal models, particularly in adipose tissue, liver, and skeletal muscle, where NNMT expression and metabolic outcomes can be quantified
In scientific contexts, it is referenced as a model compound for peptide stability studies, analytical method development, and molecular characterization workflows
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