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Consequently, although obesity affects hundreds of millions of people globally, GLP-1 therapies currently reach only a small fraction of eligible patients, underscoring the substantial unmet need for more convenient, scalable, and accessible treatment options

Retatrutide is administered as a once-weekly subcutaneous injection of up to 12 mg

Injecting on the same day each week, at roughly the same time, is the most important timing variable

We use variants of the peptides GLP-1 and exendin-4 (Ex4) to explore the interplay between helical propensity near the agonist N terminus and the ability to bind to and activate the receptor