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These findings initiated the study of the incretin hormone
Therefore, sphingolipid-autophagy crosstalk constitutes a pivotal regulatory nexus governing Treg stability, whose diabetic disruption propagates T1DM immunopathology by crippling immunosuppressive circuits, while pharmacologically restoring this axis emerges as a strategic therapeutic paradigm for re-establishing immune tolerance (Figure 5)
Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis , inhibits antigen processing and modulates antigen-specific immune response
95% CI, 0.35 to 3.14)
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