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While Balfaxar met the primary endpoint of hemostatic efficacy in a Phase III study and was non-inferior to the comparator, Kcentra, fatal and non-fatal arterial and venous thromboembolic complications were observed in clinical trials and post-marketing studies, and healthcare providers are advised to monitor patients for signs of thromboembolic events

Molecules, 15 (3), 12421264

doi:10.3109/03602532.2011.558093 Oguro T, Hayashi M, Nakajo S, Numazawa S, Yoshida T (1998) The expression of heme oxygenase-1 gene responded to oxidative stress produced by phorone, a glutathione depletor, in the rat liver

doi: 10.1016/j.intimp.2013.06.018