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& Weinstein, P
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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig
These variations may cause a patient to metabolize a drug too quickly, too slowly, or not at all, potentially leading to treatment failure or Adverse Drug Interactions (ADIs), which according to research is the fourth leading cause of death in the United States
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