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The main significant changes were an age-related relative decline in complex I-linked respiration and a corresponding rise of complex II-linked respiration in PBMCs

Additionally, Keap1 mutations are commonly found in NSCLCs such as LUAD and lung squamous carcinoma, and are strongly linked to poor prognosis and resistance to current treatments [55, 56, 93]

In the end, the glgb encoding the glycogen-branching enzyme was disrupted for a higher energy supplement