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This also imposes a substantial economic and social burden on healthcare systems [4]

However, they suggest that ALCAR may be an important antidepressant therapy, either alone or in conjunction with other mood enhancers, especially in those with other medical conditions who may not tolerate high dose antidepressants

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Mitochondrial glutamate generated via these catabolic pathways can be exported from mitochondria to the cytosol through the SLC25A18 and SLC25A22 transporters 21 , and cytosolic glutamate then participates in the biosynthesis of glutathionea tripeptide comprising glutamate, cysteine, and glycineand NEAAs (alanine, proline, aspartate, asparagine, and arginine) and is used as an exchange factor for importing extracellular cystine via SLC7A11