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Various pre-clinical and clinical studies have revealed the hepatoprotective effect of semaglutide in NASH and neuroprotective effect in Parkinsons and Alzheimers disease

Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects

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At the tissue level, GLP-1 agonists diminish ectopic fat accumulation in the liver and muscle, enhancing insulin sensitivity