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To make it work, they have to understand that its dosed slowly and low to mitigate the side effects, and that you really do have to be on a high-protein, low-calorie diet, you have to eat healthy, and you have to exercise, Apovian said
Compared with the metformin plus sulfonylurea combination, the lowest risk for all three investigated endpoints, namely MACE, severe hypoglycemia, and all cause-mortality, was seen for people treated with metformin in combination with SGLT2is and GLP-1RAs (HR, 0.53 [95% CI, 0.350.80] for MACE
doi: 10.1111/DOM.12251 33 MatsumuraKSugiuraT
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