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It does not interact negatively with semaglutide, tirzepatide, or other GLP-1 medications
They also conducted an explicit water simulation of the insulin dimer to demonstrate key inter-residue interactions between each monomer involved in the dimerization
In animal studies, DSIP demonstrated anxiolytic effects, reducing anxiety-like behavior in mice (Shekunova et al., 2002), and lowering plasma corticosterone levels in rats (Kovalzon et al., 1997)
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