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Among them, 12/15-LOX activity is significantly upregulated in AD brains, and its inhibition rescues memory and learning deficits in mouse models (303)
Reddy R, Sahebarao MP, Mukherjee S, Murthy JN
183 The recruitment of these proteins leads to the formation of the death-inducing signaling complex, which induces the internalization of the receptor, and apoptotic reactions ensure via either caspase- or mitochondrial-mediated cascades
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