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Introduction Neurodegenerative conditions are characterized by a gradual decline in neurons within both the central and peripheral nervous systems, leading to impaired motor and cognitive abilities ( Adult stem cells known as MSCs possess the ability to regenerate themselves and can differentiate into various cell lineages ( EVs are composed of a lipid bilayer and are produced and secreted by nearly every living cell ( Classification and biogenesis of EVs In 2018, the International Society for Extracellular Vesicles (ISEV) revised its research criteria and gave EVs a new meaning

Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8

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