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The disease burden was similarly calculated as the sum of the histopathological changes in a mouse and severity of neoplastic and renal lesions was assessed using an established grading system
and a probiotic approach of administering butyrate-producing bacteria
Suppression of Mn-SOD expression using small interfering RNA increased superoxide production by approximately 70% in HGSOC cells, which led to enhanced cell proliferation in vitro and increased aggressiveness of tumor growth in vivo
Funding This paper was supported by the National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre
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