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Figure 2 Exenatide, a peptide of 39 amino acids, has a much slower metabolism than endogenous GLP-1 (half-life of 3-4 h) (119, 120)

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Particularmente, el ensayo SELECT publicado en el New England Journal of Medicine sobre semaglutida y riesgo cardiovascular mostr una reduccin del 20% en eventos cardiovasculares mayores en pacientes con obesidad sin diabetes previa, lo que cambi radicalmente el paradigma de uso de estos medicamentos

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