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The combination of decreased glucose uptake by the muscle and decreased glycogenesis further contributes to hyperglycemic conditions and complicates the already challenging task of treating cancer in individuals managing diabetes
These early changes are not universal
Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds
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